Literature

OBJECTIVES 1. Describe the synthesis of the major hormones that regulate metabolism. A. Insulin B. Glucagon C. Glucocorticoids D. Epinephrine/Norepinephrine 2. continue the signaling transduction of the hormones. sensory receptor polarity cascade 3. Explain the biochemical make of the hormones on metabolism. A. Carbohydrate B. Lipid C. Protein 4. Explain the biochemical abnormalities associated with hormones that regulate metabolism. Hypersecretion Hyposecretion SYNTHESIS OF INSULIN (Remember: multitude 1 steroid hormones gathering 2 peptide hormones Group 3 - peptide hormones that wear steroid desire properties) *insulin is in group 2, so its sensory receptor is in the plasma membrane, and it is synthesized as a large whit therefore undergoes modification. [pic] 1. Preproinsulin: MW = 11,500 ? Pre or Leader chronological sequence: 23 hydrophobic amino acids; function is to guide preproinsulin to squeeze going to the ER. Once in the ER, the drawing card sequence is then cleaved to take shape proinsulin. ? components: leader sequence, A and B grasps and C peptide kitchen range 2. Proinsulin: MW = 9000 ? Sequence: B chain C peptide A chain ? C peptide dictates where disulfide fond regards should be located.

MATURE INSULIN ? A humiliated protein (MW: 5700) that consists of two chains, A and B linked by disulfide bridge from cysteine residues ? A chain: 21 amino acids, B chain: 30 AAs = 51 AAs ? 2 Inter-chain S-S bridges that marry A & B chains: A7 to B7, and A20 to B19 ? A 3rd intrachain disulfide bond connects residues A6 to A11 ? Does not exist as be on insulin alone, it is precipitated with zinc Receptor enzyme: Receptor Tyrosine kinase * equal to phosphorylate critical tyrosine residues which are set up in the B subunit *2 extra-cellular ? sub-units that contain the Insulin binding domains *2 transmembrane ? sub-units that contain the Protein...If you motive to get a full essay, nightclub it on our website: Orderessay

If you want to get a full information about our service, visit our page: How it works.